牙周翻瓣术联合应用盐酸米诺环素治疗慢性牙周炎的临床效果(1)
【摘要】 目的：研究牙周翻瓣术联合盐酸米诺环素治疗慢性牙周炎的效果。方法：选取2015年9月1日-2018年9月1日在笔者所在医院治疗的慢性牙周炎患者108例，采用随机方法将其分为两组，每组54例。对照组采用牙周翻瓣术进行治疗，观察组在对照组的基础上应用盐酸米诺环素治疗。比较两组治疗前及治疗后6周及6个月的临床牙周指数，包括临床附着丧失(clinical attachment loss，CAL)、龈沟出血指數(sulcus bleeding index，SBI)及探诊深度(probing depth，PD)。结果：治疗后6周及6个月两组患者各项临床牙周指数均较治疗前明显降低(P<0.05)。观察组治疗后6周及6个月SBI及PD均显著低于对照组，差异有统计学意义(P<0.05)，但两组治疗后6周及6个月CAL比较差异均无统计学意义(P>0.05)。结论：在慢性牙周炎治疗中，采用牙周翻瓣术联合盐酸米诺环素的改善效果优于单一牙周翻瓣术，有利于临床治疗。
【关键词】 牙周翻瓣术 盐酸米诺环素 慢性牙周炎
[Abstract] Objective： To investigate the curative effects of periodontal flap surgery combined with Minocycline Hydrochloride in the treatment of chronic periodontitis. Method： A total of 108 patients with chronic periodontitis who were treated in our hospital from September 1st， 2015 to September 1st， 2018 were selected and randomly divided into two groups， with 54 case in each group. The control group was treated with periodontal flap surgery， and the observation group was treated with Minocycline Hydrochloride on the basis of the control group. The clinical periodontal index， including clinical attachment loss (CAL)， sulcus bleeding index (SBI) and probing depth (PD) were compared between the two groups before and 6 weeks and 6 months after treatment. Result： After 6 weeks and 6 months of treatment， the clinical periodontal index of the two groups were significantly lower than those before treatment (P<0.05). The SBI and PD of the observation group were significantly lower than those of the control group at 6 weeks and 6 months after treatment， the differences were statistically significant (P<0.05)， but there were no significant differences in CAL between the two groups at 6 weeks and 6 months after treatment (P>0.05). Conclusion： In the treatment of chronic periodontitis， the improvement effect of periodontal flap surgery combined with Minocycline Hydrochloride is better than that of single periodontal flap surgery and is conducive to clinical treatment.
慢性牙周炎是人类常见的口腔疾病之一[1]，多由局部因素导致牙周组织产生慢性炎症、牙齿丧失，发病人群多为35岁以上的成年人。菌斑微生物是造成慢性牙周炎的主要原因，前期通过龈上洁及龈下刮治术清除牙菌斑，病情严重的患者仅依靠上述方法难以根治疾病，需要结合牙周翻瓣术并配合抗生素以获得更好的效果。牙周翻瓣术是指通过采用不同的手术切口分离牙龈与下方的组织，使牙龈组织瓣形成，并使根面和牙槽骨的病变区暴露，为清创提供可视性[2]。将病变组织及菌斑牙石刮除后，使牙龈瓣复位后在合适的位置进行缝合，最终牙周袋变浅或消除。盐酸米诺环素(Minocycline Hydrochloride)是一种四环素类抗生素，临床上通过局部使用2%的盐酸米诺环素凝胶治疗慢性牙周炎，其可使龈沟液中的胶原酶活性降低，从而使牙周组织的破坏减轻，使牙周致病菌的生长受到抑制[3]。盐酸米诺环素是一种pH偏中性的酸性根面处理剂，可使牙周膜玷污层去除，细胞黏附并在根面增殖，用于辅助牙周翻瓣术，较单纯的翻瓣术效果更佳。因此，本研究选取2015年9月1日-2018年9月1日在笔者所在医院治疗的慢性牙周炎患者108例，观察牙周翻瓣术联合应用盐酸米诺环素治疗慢性牙周炎的临床效果，现报道如下。, 百拇医药(何柳静)
【关键词】 牙周翻瓣术 盐酸米诺环素 慢性牙周炎
[Abstract] Objective： To investigate the curative effects of periodontal flap surgery combined with Minocycline Hydrochloride in the treatment of chronic periodontitis. Method： A total of 108 patients with chronic periodontitis who were treated in our hospital from September 1st， 2015 to September 1st， 2018 were selected and randomly divided into two groups， with 54 case in each group. The control group was treated with periodontal flap surgery， and the observation group was treated with Minocycline Hydrochloride on the basis of the control group. The clinical periodontal index， including clinical attachment loss (CAL)， sulcus bleeding index (SBI) and probing depth (PD) were compared between the two groups before and 6 weeks and 6 months after treatment. Result： After 6 weeks and 6 months of treatment， the clinical periodontal index of the two groups were significantly lower than those before treatment (P<0.05). The SBI and PD of the observation group were significantly lower than those of the control group at 6 weeks and 6 months after treatment， the differences were statistically significant (P<0.05)， but there were no significant differences in CAL between the two groups at 6 weeks and 6 months after treatment (P>0.05). Conclusion： In the treatment of chronic periodontitis， the improvement effect of periodontal flap surgery combined with Minocycline Hydrochloride is better than that of single periodontal flap surgery and is conducive to clinical treatment.
慢性牙周炎是人类常见的口腔疾病之一[1]，多由局部因素导致牙周组织产生慢性炎症、牙齿丧失，发病人群多为35岁以上的成年人。菌斑微生物是造成慢性牙周炎的主要原因，前期通过龈上洁及龈下刮治术清除牙菌斑，病情严重的患者仅依靠上述方法难以根治疾病，需要结合牙周翻瓣术并配合抗生素以获得更好的效果。牙周翻瓣术是指通过采用不同的手术切口分离牙龈与下方的组织，使牙龈组织瓣形成，并使根面和牙槽骨的病变区暴露，为清创提供可视性[2]。将病变组织及菌斑牙石刮除后，使牙龈瓣复位后在合适的位置进行缝合，最终牙周袋变浅或消除。盐酸米诺环素(Minocycline Hydrochloride)是一种四环素类抗生素，临床上通过局部使用2%的盐酸米诺环素凝胶治疗慢性牙周炎，其可使龈沟液中的胶原酶活性降低，从而使牙周组织的破坏减轻，使牙周致病菌的生长受到抑制[3]。盐酸米诺环素是一种pH偏中性的酸性根面处理剂，可使牙周膜玷污层去除，细胞黏附并在根面增殖，用于辅助牙周翻瓣术，较单纯的翻瓣术效果更佳。因此，本研究选取2015年9月1日-2018年9月1日在笔者所在医院治疗的慢性牙周炎患者108例，观察牙周翻瓣术联合应用盐酸米诺环素治疗慢性牙周炎的临床效果，现报道如下。, 百拇医药(何柳静)
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